Welcome to a new article on the reaction and reagent question-answer series for a beginner to advance level Examination aspirant. Discussing the conceptual questions-answer series with a proper solution for CSIR NET, GATE, IIT JAM, and other entrance examinations like DRDO, NTPC, BHU, DU, etc. This session starts on the Chemclip or Chemarticle website you can follow the link given below.
Preparation of Organic Chemistry
The reagent and their reaction mechanism are important chapters in organic chemistry for any national-level examinations aspect. First of all, we have to release the session for learning from beginner to Advanced. We hope that it is helpful for your exam preparation.
Questions and Answers in reagents and reaction mechanism
The session of reagents questions with solutions from the Carruthers series. In this session, we have to talk about a few different questions.
| Organic Reagents | Topic |
|---|---|
| Organic Reagents and Reagent Question-1 solution | Alkylation Using LDA Reagents – Carruthers book for modern organic synthesis – Carbon-Carbon signal bond formation with reaction mechanism. |
| Organic Reagents and Reagent Question-2 solution | Alkylation ketone Using KOH, Bu4NBr, and MeI Reagents – Carruthers book for modern organic synthesis – Carbon-Carbon signal bond formation with reaction mechanism. |
| Organic Reagents and Reagent Question-3 solution | Alkylation ketone Using LDA, THF, and benzyl halide Reagents – Carruthers book for modern organic synthesis – Carbon-Carbon signal bond formation with reaction mechanism. |
| Organic Reagents and Reagent Question-4 solution | Alkylation ketone Using t-BuOK, t-BuOH, and MeI Reagents – Carruthers book for modern organic synthesis – Carbon-Carbon signal bond formation with reaction mechanism. |
| Organic Reagents and Reagent Question-5 solution | Alkylation ketone Using t-BuOK, t-BuOH, and MeI Reagents and protection using: (i) Na-OEt, EtOH, HCO2Et (ii) BuSH, TsOH deprotection: KOH, H2O, ethylene glycol, reflux Carruthers book for modern organic synthesis – Carbon-Carbon signal bond formation with reaction mechanism. |
| Organic Reagents and Reagent Question-6 solution | Reagent KNH2 liquid ammonia| Reaction Mechanism -Carruthers book for modern organic synthesis – Carbon-Carbon signal bond formation with reaction mechanism. |
| Organic Reagents and Reagent Question-7 solution | Reagents NaH, BuLi, and Alkyl bromide| Reaction Mechanism -Carruthers book for modern organic synthesis – Carbon-Carbon signal bond formation with reaction mechanism. |
| Organic Reagents and Reagent Question-8 solution | Reagents BuLi with Nitroalkanes| Reaction Mechanism -Carruthers book for modern organic synthesis – Carbon-Carbon signal bond formation with reaction mechanism. |
List of Reagents Chemistry
Very important reagents are list up in below: Chemclip helps to read about the reaction mechanism of those reagents. Think of a make theory concept of those reaction mechanisms under the reagents then solve the questions. This is the syllabus of reagents chemistry for the entrance examination, Masters of chemistry, Bachelor of Science in the chemistry degree program.
| No. | Reagents | Reagents Name and Structure |
|---|---|---|
| 1. | R2CuLi | Gilman Reagent |
| 2. | RMgX | Grignard Reagent |
| 3. | DDC | N, N′-Dicyclohexylcarbodiimide |
| 4. | Bu3SnH | Tributyltin Hydride |
| 5. | DDQ | 2,3-Dichloro-5,6-dicyano-1,4-benzoquinone |
| 6. | LDA | Lithium Di-isopropyl Amide (LDA) |
| 7. | R-Li | Organolithium |
| 8. | Hydration | BH3, B2H6, Hg(OAc)2, NaBH4 |
| 9. | Hydrogenolysis | |
| 10. | LiAH4 | Lithium Aluminium Hydride (Powerful reducing agent) |
| 11. | NaBH4 | Sodium borohydride (Reducing agent) |
| 12. | Zn(BH4)2 | Zinc Borohydride (Reducing agent) |
| 13. | DIBAL-H | Diisobutylaluminium hydride |
| 14. | NBS | N-BromoSuccinimide |
| 15. | Raney Ni | Raney Ni |
| 16. | H2O2 | Hydrogen peroxide |
| 17. | tBuOOH | tert-Butyl hydroperoxide |
| 18. | Sharpless Oxidation | tBuOOH, Ti(Oi-Pr)4, (+)DET or (-)DET [ Where Ti(Oi-Pr)4 is Titanium(IV) isopropoxide and DET is chiral diethyl tartrate. |
| 19. | Peroxy acid | RCO3H |
| 20 | Jacobsen epoxidation | Oxidizing reagent (Alkene to epoxide formation.) |
| 21. | OsO4 | Osmium tetroxide (It is an oxidizing reagent) |
| 22. | Lemieux Johnson Oxidation | OsO4 or RuO4 Catalyst, NaIO4 |
| 23. | Lead Tetraacetate | Lead Tetraacetate: Pb(OAc)4 |
| 24. | KMnO4 | Potassium permanganate (Oxidizing agent) |
| 25. | MnO4 | Permanganate (Oxidizing agent) |
| 26. | Oxidation of Alcohol | |
| 27. | Ag2CO3 | Silver carbonate |
| 28. | PCC | Pyridinium Chlorochromate (is an Oxidizing agent) |
| 29. | PDC | Pyridinium dichromate (is an oxidizing agent) |
| 30. | Oxidation by DMSO | Swern Oxidation: DMSO, (COCl)2 -60oC in the presence of NEt3 (Base) and absence of base. |
| 31. | SeO2 | Selenium dioxide (Is an oxidizing agent) |
| 32. | Ozonolysis | O3, Zn/ H2O |
| 33. | TEMPO | 2,2,6,6-Tetramethylpiperidinyloxy |
| 34. | IBX and Dess Martin | 2-Iodoxybenzoic acid |
What is the best book for reagents and reaction mechanism chemistry?
We have to suggest a few best books for reaction and reagents chemistry. A textbook on Organic synthesis by Clayden is good for beginners and corresponds to advance students. Clayden’s book on Organic synthesis is clear the concept of the reaction mechanism of basic knowledge under organic chemistry.
Advanced Organic Synthesis Books
Few organic reagents: organolithium catalyzed, organometallic catalyzed, Grignard reagent, Gilman reagent, etc. Correspond to nucleophile, electrophile, and acid-basic reagents commonly used in a regular organic reaction.
- And another book for advanced level students and research fellows are following this book is Carruthers book for modern organic synthesis.
One of the most famous and popular books is A Guide to Mechanisms in organic synthesis by Peter Sykes. This book is good for any beginner-level student’s purpose to learn and concept clearing under the reaction mechanism.
How to solve the reaction mechanism and reagent questions without any time lost in the exam hall?
First of all, students must have concepts in basic knowledge of the organic reaction like nucleophilic addition, electrophilic substitution, and acid-base reaction.
Confident in the subject topic:
Clear your concept under the electrophile attack priority or nucleophile attack priority or acid-base reaction priority. Which depends on the stability of the electrophile, nucleophile, or acid-base reagent.
- The reagents used in a reaction belong in the category mentioned earlier. The category follows, and the Reagent has belonged which characterized.
- That causes to identify the reasons belong to which categories easily. then reactant is which categories belong to mention and carefully follow these steps.
Try to solve the problem:
Above all these knowledgeable pieces of information are how to read the reaction mechanism for beginners. If you can follow those steps, then you can easily solve the question of reagents and reaction mechanisms under any examination.
Followed those books reactions which are mention in above. That helps you to practice and better prepare For any entrance examinations.
Reference:
- Modern Organic Synthesis by Carruthers book
- Organic Chemistry book by Clayden
- Organic Chemistry Volume-1 I.L Finar
- A guidebook to mechanism in Organic chemistry by Peter Sykes
- And other Research Articles on Organic Reagents.
- Informative article from Google webpage.