Hello, everyone this day we will discuss the Nobel prize winner on click chemistry 2022 with relative Research article and their relative chemical reaction also.
First of all, we have required some knowledge of click chemistry. So firstly we have to learn what is click chemistry and how it works. what are the benefits of this tool? so let’s start
What is click chemistry?
Click chemistry is a term used to describe a set of rapid, highly selective, and reliable chemical reactions that can be used to join together small organic molecules to form more complex structures. The term “click” refers to the fast and efficient nature of the reaction, which can be performed in a matter of seconds or minutes, with high yields and low toxicity. The most well-known click reaction is the copper(I)-catalyzed azide-alkyne cycloaddition, which involves the reaction of an azide and an alkyne to form a triazole.
Click chemistry is widely used in many areas of research, including synthetic organic chemistry, materials science, biotechnology, and drug discovery. Its ease of use and high efficiency make it a powerful tool for the synthesis of new compounds, the modification of existing compounds, and the preparation of complex molecular architectures.
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| Click chemistry Reaction source |
Nobel prize winner on click chemistry
K. Barry Sharpless, who was awarded the Nobel Prize in Chemistry in 2001, is widely recognized as one of the pioneers of click chemistry. He is best known for his work on the development of the copper(I)-catalyzed azide-alkyne cycloaddition reaction, which is the most well-known and widely used click reaction.
Sharpless and his colleagues demonstrated the high efficiency, specificity, and versatility of the azide-alkyne cycloaddition reaction, and showed that it could be used for the synthesis of a wide range of compounds, including polymers, natural products, and bioactive molecules. The success of the azide-alkyne cycloaddition reaction helped to establish the concept of click chemistry and paved the way for the development of other click reactions.
Throughout his career, Sharpless has been a leader in the field of organic chemistry and has made many significant contributions to the development of new reaction methods and the synthesis of complex molecules. His work on click chemistry has had a profound impact on modern chemistry and has opened up new avenues of research in a wide range of fields, including materials science, drug discovery, and synthetic biology.
How to work click chemistry in cancer cells?
Click chemistry has been applied in various ways to study cancer cells and to develop new cancer treatments. Here are a few examples of how click chemistry is being used in cancer research:
1. Targeted drug delivery:
Researchers are using click chemistry to design and synthesize new nanocarriers that can selectively target cancer cells and deliver therapeutic agents directly to the site of the tumor. For example, researchers have used click reactions to conjugate small-molecule drugs or siRNA to nanoparticles, which can be selectively taken up by cancer cells and used to inhibit the growth and spread of the tumor.
2. Imaging probes:
Researchers are using click chemistry to develop new imaging probes that can be used to visualize cancer cells and monitor the progression of the disease. For example, researchers have used click reactions to conjugate fluorescent dyes or radiolabels to small-molecule probes that can be selectively taken up by cancer cells and used to track the distribution and metabolism of the tumor.
3. Antibody-drug conjugates:
Researchers are using click chemistry to synthesize new antibody-drug conjugates (ADCs), which are chimeric molecules that consist of a monoclonal antibody linked to a small-molecule drug. ADCs can be used to target cancer cells and deliver the drug directly to the site of the tumor, thus reducing the side effects associated with traditional chemotherapy.
4. Synthetic biology:
Researchers are using click chemistry to develop new tools and technologies for synthetic biology that can be used to engineer cells for the treatment of cancer. For example, researchers have used click reactions to create new biosensors for monitoring cellular processes, to create new vaccines and immunotherapies, and to engineer cells for the production of therapeutic proteins.
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| Work click chemistry in cancer cells SOURCE |
Conclusion:
These examples demonstrate the versatility and potential of click chemistry in the study and treatment of cancer. By using click chemistry to synthesize new compounds and materials, researchers can gain a deeper understanding of cancer biology and develop new and effective treatments for this devastating disease.
A few Research Articles for click chemistry help you to understand more
Here is a list of some influential research articles on click chemistry:
- “Copper(I)-catalyzed Azide-Alkyne Cycloaddition: A Journey from Concept to Applications” by K. Barry Sharpless and Rachel E. Martin, Chemical Reviews, 2011, vol. 111, pp. 3967-4004.
- “Click Chemistry: Diverse Chemical Function from a Few Good Reactions” by Christopher W. Bielawski and K. Barry Sharpless, Angewandte Chemie International Edition, 2002, vol. 41, pp. 2056-2078.
- “Click Chemistry for Material Science” by Jaap Cornelissen, Tammo Havenith, and Martien A. Cohen Stuart, Chemical Reviews, 2010, vol. 110, pp. 3888-3930.
- “The Application of Click Chemistry in Drug Discovery” by Wei-Min Dai and Wei Yang, Nature Reviews Drug Discovery, 2009, vol. 8, pp. 285-298.
- “Click Chemistry in Synthetic Biology” by Mark J. MacCoss, Mu-ming Poo, and David Baker, Nature Methods, 2008, vol. 5, pp. 561-567.
These articles provide a comprehensive overview of the history and development of click chemistry, as well as its applications in various fields. They highlight the key advantages of click chemistry, such as its specificity, speed, efficiency, and versatility, and discuss the challenges and limitations of the technology. These articles are essential reading for anyone interested in learning more about click chemistry and its impact on modern chemistry and related fields.
Recent work on click chemistry
Since the concept of click chemistry was first introduced in the late 1990s and early 2000s, there has been a tremendous amount of research activity in this area. Here are a few examples of recent work in the field of click chemistry:
1. Development of new click reactions:
Researchers have continued to develop new click reactions that are faster, more efficient, and more versatile than the original copper(I)-catalyzed azide-alkyne cycloaddition. For example, researchers have developed the copper(I)-catalyzed alkyne-ene reaction, the copper(I)-catalyzed cyclooctyne-azide reaction, and the copper(I)-free azide-alkyne cycloaddition.
2. Applications in material science:
Click chemistry has been applied to the synthesis of a wide range of materials, including polymers, hydrogels, and nanoparticles. For example, researchers have used click reactions to create functional materials with unique properties, such as materials that respond to specific stimuli, materials that can self-heal, and materials that can release drugs in a controlled manner.
3. Applications in drug discovery:
Click chemistry has been used in the discovery and development of new drugs, particularly in the area of chemical biology. For example, researchers have used click reactions to create small-molecule inhibitors of protein-protein interactions, to create probes for imaging and targeting specific proteins in cells, and to synthesize new drugs that target specific diseases.
4. Applications in synthetic biology:
Click chemistry has been used in the development of new tools and technologies for synthetic biology. For example, researchers have used click reactions to create new genetic parts and pathways for engineering cells, to create new biosensors for monitoring cellular processes, and to create new vaccines and immunotherapies.
Conclusion:
These examples demonstrate the continued innovation and impact of click chemistry in the fields of materials science, drug discovery, and synthetic biology. The future of click chemistry is bright, and it is likely that new and exciting applications of this technology will emerge in the coming years.
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