Hello, everyone today we will discuss the reaction mechanism of KNH2 and liquid ammonia reagent in presence of diketone.
This is a reagent and reaction mechanism questions answer series for any entrance examination like CSIR UGC NET GATE IIJ JAM. This section is for a beginner and corresponds to advance students in chemical science. Likewise, beginner students like B.sc, Master in chemistry, chemical engineering, etc all follow this section which is helpful. Learning chemical science in the proper way. And achieve a master of chemical science degree from any national-level college or university or school.
Problem-solve:
First of all, read the questions carefully and try to understand your best knowledge from the basic reagent theory class. If your reaction mechanism concept has clear then you can try to solve this question easily.
Q.6. Major product Y form Following the reaction: where X is Intermediate. Predict the major product Y and Intermediate X with the proper mechanism.
Answer: Question no.6: Reagents and reaction
In this reaction use of reagent potassium amide in presence of di-ketone form enolate as an intermediate. After the addition of haloalkane transfer from enolate to Alpha addition product due to carbon-carbon bond formation.
Reaction mechanism of question no.6 in the Reaction and reagents section
The reagent potassium amide act as a base in presence of liquid ammonia. It abstracts the alpha hydrogen in the carbonyl compound. Given the following reaction using 2 equivalent potassium amide (KNH2). We have to see that two acidic hydrogens are present in the dicarbonyl compound. two hydrogens are abstract by KNH2 one by one.
Reference:
The very important and popular book in organic chemistry by Carruthers. The book was read to solve chemistry problems on the reaction mechanism and the reagent section corresponds to oxidizing reagents and reducing agents. Those topics are very briefly discussed. For the basic approach to reaction mechanism, you can follow the organic chemistry book by Clayden.
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